A primate-specific functional GTTT-repeat in the core promoter of CYTH4 is linked to bipolar disorder in human.

@article{Rezazadeh2015APF,
  title={A primate-specific functional GTTT-repeat in the core promoter of CYTH4 is linked to bipolar disorder in human.},
  author={Maryam Rezazadeh and Jalal Gharesouran and Arash Mirabzadeh and Hamid Reza Khorram Khorshid and Akbar Biglarian and Mina Ohadi},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2015},
  volume={56},
  pages={161-7}
}
Evidence of primate-specific genes and gene regulatory mechanisms linked to bipolar disorder (BD) lend support to evolutionary/adaptive processes in the pathogenesis of this disorder. Following a genome-scale analysis of the entire protein coding genes annotated in the GeneCards database, we have recently reported that cytohesin-4 (CYTH4) contains the longest tetra-nucleotide short tandem repeat (STR) identified in a human protein-coding gene core promoter, which may be of adaptive advantage to… CONTINUE READING
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