• Corpus ID: 2876235

A primate model of polydrug abuse: cocaine and heroin combinations.

@article{Mello1995APM,
  title={A primate model of polydrug abuse: cocaine and heroin combinations.},
  author={Nancy K. Mello and S Stevens Negus and Scott E. Lukas and Jack H. Mendelson and J. Wallis Sholar and John Drieze},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={274 3},
  pages={
          1325-37
        }
}
  • N. Mello, S. Negus, +3 authors J. Drieze
  • Published 1 September 1995
  • Psychology, Medicine
  • The Journal of pharmacology and experimental therapeutics
Abuse of cocaine-opiate combinations ("speedballs") reported clinically was simulated in a rhesus monkey model of simultaneous cocaine and heroin self-administration. The reinforcing effects of nine cocaine-heroin combinations (cocaine [0.001, 0.01 and 0.10 mg/kg per injection i.v.] and heroin [0.0001, 0.001 and 0.01 mg/kg per injection i.v.]) were evaluated for 10 days on a second-order fixed ratio of 4 (variable ratio of 16:S) schedule and compared with self-administration of cocaine and… 
The effects of buprenorphine on self-administration of cocaine and heroin "speedball" combinations and heroin alone by rhesus monkeys.
  • N. Mello, S. Negus
  • Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1998
TLDR
Buprenorphine's selective reduction of speedball and heroin self-administration is consistent with clinical treatment trials in opioid abusers and polydrug abusers and should be useful for preclinical evaluation of novel drug abuse treatment medications.
Self-administration of cocaine-heroin combinations by rhesus monkeys: antagonism by naltrexone.
TLDR
In vivo apparent pA2 and pKB analyses of these data revealed values of approximately 8.0, consistent with a role for mu opioid receptors in the self-administration of heroin and cocaine-heroin (i.e., "speedball") combinations.
Self-administration of cocaine-pentobarbital mixtures by rhesus monkeys.
A number of experiments have evaluated self-administration of the combination of a stimulant and an opioid. Less is known about the combination of a stimulant and a CNS depressant. The present
Discriminative stimulus effects of a cocaine/heroin "speedball" combination in rhesus monkeys.
TLDR
It is suggested that a combination of cocaine and heroin produces a pharmacologically selective discriminative stimulus complex that includes aspects of both component drugs.
Effects of Flupenthixol and Quadazocine on Self-Administration of Speedball Combinations of Cocaine and Heroin by Rhesus Monkeys
TLDR
The findings suggest that medication mixtures designed to target both the stimulant and opioid component of the speedball combination, may be an effective approach to polydrug abuse treatment.
Comparison of the Reinforcing Effects of Cocaine and Cocaine/Heroin Combinations under Progressive Ratio and Choice Schedules in Rats
TLDR
Results obtained using the PR schedule do not support the hypothesis that speedball combinations are more reinforcing than cocaine alone, but data from the choice procedure do support this hypothesis, and suggest that choice procedures in rats provide a useful tool to study speedball self-administration.
Intravenous self-administration of heroin, cocaine, and the combination in Balb/c mice.
TLDR
It is hypothesized that heroin may interact with effects of cocaine that function to limit self-administration in Balb/c mice, facilitating the acquisition and maintenance of self-Administration of cocaine + heroin combinations.
Effects of Heroin/Cocaine Combinations in Rats Trained to Discriminate Heroin or Cocaine from Saline
TLDR
It is suggested that combinations of heroin and cocaine usually produce discriminative stimulus effects similar to either heroin or cocaine alone.
Self-Administered Heroin and Cocaine Combinations in the Rat: Additive Reinforcing Effects—Supra-Additive Effects on Nucleus Accumbens Extracellular Dopamine
TLDR
Data indicate that although the interaction between cocaine and heroin in maintaining self-administration is additive, a potentiation of NAc dopaminergic neurotransmission is present, suggesting that NAc [DA]e may not be a direct measure of reinforcing efficacy and/or it is not central to the mediation of the self-Administration of this drug combination.
Discriminative Stimulus Effects of a Cocaine / Heroin “ Speedball ” Combination in Rhesus Monkeys 1
Cocaine and heroin often are abused together in a combination known as a “speedball,” but relatively little is known about ways in which cocaine and heroin may interact to modify each other’s
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