A primary tumor promotes dormancy of solitary tumor cells before inhibiting angiogenesis.

  title={A primary tumor promotes dormancy of solitary tumor cells before inhibiting angiogenesis.},
  author={Markus Guba and Grigore Cernaianu and Gudrun Koehl and Edward Kenneth Geissler and K. W. Jauch and Matthias Anthuber and Werner Falk and Markus Steinbauer},
  journal={Cancer research},
  volume={61 14},
Mechanisms that regulate the transition of micrometastases from clinically undetectable and dormant to progressively growing are critically important but poorly understood in cancer biology. Here we examined the effect of a primary tumor on the growth of solitary tumor cells in the mouse liver, as well as on the development of tumor angiogenesis in a dorsal skin-fold chamber. s.c. placement of a CT-26 (BALB/c-derived mouse colon carcinoma) primary tumor markedly inhibited development of liver… CONTINUE READING


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