A primary amelanotic melanoma of the vagina, diagnosed by immunohistochemical staining with HMB-45, which recurred as a pigmented melanoma.

@article{Oguri2004APA,
  title={A primary amelanotic melanoma of the vagina, diagnosed by immunohistochemical staining with HMB-45, which recurred as a pigmented melanoma.},
  author={Hiroyoshi Oguri and Chiaki Izumiya and Nagamasa Maeda and Takashi Fukaya and Toshiaki Moriki},
  journal={Journal of clinical pathology},
  year={2004},
  volume={57 9},
  pages={986-8}
}
Usually, malignant melanoma is readily diagnosed by the presence of melanin granules. Although amelanotic melanoma contains a few melanin granules, it is often difficult to differentiate from non-epithelial malignant tumours. This report describes a case of amelanotic melanoma of the vagina, which was originally suspected to be a non-epithelial malignant tumour, but was subsequently correctly diagnosed by immunohistochemical staining with the HMB-45 antibody and for the S-100 protein. A light… CONTINUE READING

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