A previously unidentified host protein protects retroviral DNA from autointegration.

  title={A previously unidentified host protein protects retroviral DNA from autointegration.},
  author={Myoyong Lee and Robert Craigie},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 4},
Integration of a DNA copy of the viral genome into a host chromosome is an essential step in the retrovirus life cycle. The machinery that carries out the integration reaction is a nucleoprotein complex derived from the core of the infecting virion. To successfully integrate into host DNA, the viral DNA within this complex must avoid self-destructive integration into itself, a reaction termed autointegration. We have previously shown [Lee, M. S. and Craigie, R. (1994) Proc. Natl. Acad. Sci. USA… CONTINUE READING
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