A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

  title={A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis},
  author={Ming Yan and Eiki Kanbe and L. F. A. Peterson and Anita Boyapati and Yuqin Miao and Yang Wang and I-Ming Chen and Zixing Chen and Janet D. Rowley and Cheryl L. Willman and Dong-Er Zhang},
  journal={Nature Medicine},
The t(8;21)(q22;q22) translocation is one of the most common genetic abnormalities in acute myeloid leukemia (AML), identified in 15% of all cases of AML, including 40–50% of FAB M2 subtype and rare cases of M0, M1 and M4 subtypes. The most commonly known AML1-ETO fusion protein (full-length AML1-ETO) from this translocation has 752 amino acids and contains the N-terminal portion of RUNX1 (also known as AML1, CBFα2 or PEBP2αB), including its DNA binding domain, and almost the entire RUNX1T1… CONTINUE READING
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