A presynaptic mechanism accounts for the differential block of nicotinic synapses on sympathetic B and C neurons by d-tubocurarine.

@article{Shen1995APM,
  title={A presynaptic mechanism accounts for the differential block of nicotinic synapses on sympathetic B and C neurons by d-tubocurarine.},
  author={Wen Shen and John P. Horn},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 7 Pt 1},
  pages={5025-35}
}
The effects of d-tubocurarine (dTC) on nicotinic synapses on sympathetic B and C neurons in the bullfrog were compared by recording trains of postganglionic compound action potentials (CAPs) at 0.5-20 Hz. Block by dTC was strongly use dependent in that the IC50 shifted almost 10-fold with increasing stimulus frequency. Maximum sensitivity to dTC occurred at 5 Hz in the B system and at 20 Hz in the C system. Recovery during posttrain periods was characterized by transient reduction of CAP… CONTINUE READING

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Use - deoendent actions of nicotinic blockers : are they presynaptic ?

  • W Shen, JP Horn
  • Sot Neuiosci Abstr
  • 1992
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Nicotinic antagonists distinguish between synapses on sympathetic B and C neurons in the bullfrog

  • Shen W-X, JP Horn
  • 1993

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