A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission.

@article{Mtchedlishvili2003APA,
  title={A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission.},
  author={Zakaria Mtchedlishvili and Jaideep Kapur},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 4},
  pages={
          857-64
        }
}
The endogenous neurosteroid pregnenolone sulfate (PS) is known to enhance memory and cognitive function at nanomolar concentrations. However, the effect of these low concentrations on synaptic transmission has not been previously studied. The effects of PS on GABAA receptor-mediated inhibitory postsynaptic currents were studied in cultured hippocampal pyramidal neurons. Concentrations of PS similar to those endogenous in the hippocampus (10-30 nM) reduced the frequency of both action potential… CONTINUE READING

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