A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

@article{Marambaud2002APC,
  title={A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.},
  author={Philippe Marambaud and Junichi Shioi and Geo Serban and Anastasios Georgakopoulos and Shula Sarner and Vanja Nagy and Lia Baki and Paul Wen and Spiros Efthimiopoulos and Zhiping Shao and Thomas Wisniewski and Nikolaos K. Robakis},
  journal={The EMBO journal},
  year={2002},
  volume={21 8},
  pages={1948-56}
}
E-cadherin controls a wide array of cellular behaviors including cell-cell adhesion, differentiation and tissue development. Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, controls a gamma-secretase-like cleavage of E-cadherin. This cleavage is stimulated by apoptosis or calcium influx and occurs between human E-cadherin residues Leu731 and Arg732 at the membrane-cytoplasm interface. The PS1/gamma-secretase system cleaves both the full-length E-cadherin and a… CONTINUE READING
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