A preoperative single course of high-dose cisplatin and bleomycin with glutathione protection in bulky stage IB/II carcinoma of the cervix.

@article{Fontanelli1992APS,
  title={A preoperative single course of high-dose cisplatin and bleomycin with glutathione protection in bulky stage IB/II carcinoma of the cervix.},
  author={Rosanna Fontanelli and Gianbattista Spatti and Francesco Raspagliesi and Franco Zunino and F. Di Re},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1992},
  volume={3 2},
  pages={117-21}
}
One course of preoperative chemotherapy including high-dose cisplatin (40 mg/m2 daily for 5 consecutive days) with glutathione protection and bleomycin (15 mg on days 2, 8 and 9) was administered to 27 patients with bulky operable cervical carcinoma (stage IB/II) in a pilot study. In all patients the tumor diameter was greater than 4 cm. Surgery (radical hysterectomy with pelvic and para-aortic lymphadenectomy) was planned within one month of chemotherapy. In 27 evaluable patients, nausea… CONTINUE READING
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