A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.

@article{Reddy1991APA,
  title={A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.},
  author={G. V. Ramana Reddy and Norikazu Ueda and Toshikazu Hada and A. C. Sackeyfio and Shozo Yamamoto and Yoshio Hano and Misako Aida and Teruko Nomura},
  journal={Biochemical pharmacology},
  year={1991},
  volume={41 1},
  pages={
          115-8
        }
}
Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the… CONTINUE READING

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