A premature termination codon mutation at the C terminus of foamy virus Gag downregulates the levels of spliced pol mRNA.

@article{Lee2008APT,
  title={A premature termination codon mutation at the C terminus of foamy virus Gag downregulates the levels of spliced pol mRNA.},
  author={Eun-gyung Lee and Daniel A. Kuppers and Megan Horn and Jacqueline Roy and Cynthia May and Maxine L. Linial},
  journal={Journal of virology},
  year={2008},
  volume={82 4},
  pages={1656-64}
}
Foamy viruses (FV) comprise a subfamily of retroviruses. Orthoretroviruses, such as human immunodeficiency virus type 1, synthesize Gag and Pol from unspliced genomic RNA. However, FV Pol is expressed from a spliced mRNA independently of Gag. FV pol splicing uses a 3' splice site located at the 3' end of gag, resulting in a shared exon between gag and pol. Previously, our laboratory showed that C-terminal Gag premature termination codon (PTC) mutations in the 3' shared exon led to greatly… CONTINUE READING

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