A preliminary study of the mechanism of nitrate-stimulated remarkable increase of rifamycin production in Amycolatopsis mediterranei U32 by RNA-seq

@inproceedings{Shao2015APS,
  title={A preliminary study of the mechanism of nitrate-stimulated remarkable increase of rifamycin production in Amycolatopsis mediterranei U32 by RNA-seq},
  author={Zhi Hui Shao and Shuang Xi Ren and Xin Liu and Jian Xu and Han Yan and Guo Ping Zhao and Jin Wang},
  booktitle={Microbial cell factories},
  year={2015}
}
BACKGROUND Rifamycin is an important antibiotic for the treatment of infectious disease caused by Mycobacteria tuberculosis. It was found that in Amycolatopsis mediterranei U32, an industrial producer for rifamycin SV, supplementation of nitrate into the medium remarkably stimulated the yield of rifamycin SV. However, the molecular mechanism of this nitrate-mediated stimulation remains unknown. RESULTS In this study, RNA-sequencing (RNA-seq) technology was employed for investigation of the… CONTINUE READING
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