A preliminary report on the derivatization-gas chromatographic determination of nalidixic acid and 3,7-dicarboxynalidixic acid in urine.

@article{Wu1989APR,
  title={A preliminary report on the derivatization-gas chromatographic determination of nalidixic acid and 3,7-dicarboxynalidixic acid in urine.},
  author={S. M. Wu and S. H. Chen and H. Wu},
  journal={Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences},
  year={1989},
  volume={5 11},
  pages={
          630-6
        }
}
  • S. M. Wu, S. H. Chen, H. Wu
  • Published 1989
  • Medicine
  • Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences
A preliminary study on the gas chromatographic analysis of urine spiked with nalidixic acid and 3,7-dicarboxynalidixic acid is described. The method is based on the transfer of an ion-pair of NA or CNA with tetradecyldimethylbenzylammonium chloride (benzalkonium chloride) from alkaline aqueous solution into methyl isobutyl ketone (MIBK), the organic phase, where these salts are derivatized with pentafluorobenzyl bromide. The derivatives formed by this process are chromatographed on an… Expand