A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation.

@article{George2003APP,
  title={A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation.},
  author={Tony P George and Jennifer C Vessicchio and Angelo Termine and Peter I. Jatlow and Thomas R. Kosten and Stephanie S O'Malley},
  journal={Biological psychiatry},
  year={2003},
  volume={53 2},
  pages={136-43}
}
BACKGROUND Since dopaminergic mechanisms appear to be involved in nicotine dependence, we studied the safety and efficacy of the monoamine oxidase B inhibitor selegiline hydrochloride compared with placebo for smoking cessation in nicotine-dependent cigarette smokers. METHODS Forty subjects with DSM-IV nicotine dependence were randomized to: 1) selegiline hydrochloride (5 mg p.o. twice daily) or 2) placebo in an 8-week trial. Outcome measures included smoking cessation rates, treatment… CONTINUE READING

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