A preliminary operational classification system for nonmutagenic modes of action for carcinogenesis.

@article{Hattis2009APO,
  title={A preliminary operational classification system for nonmutagenic modes of action for carcinogenesis.},
  author={Dale B. Hattis and Miyoko Chu and Nilufer Rahmioglu and Robert L. Goble and Priti Verma and Kristen Hartman and Mary Kozlak},
  journal={Critical reviews in toxicology},
  year={2009},
  volume={39 2},
  pages={97-138}
}
This article proposes a system of categories for nonmutagenic modes of action for carcinogenesis. The classification is of modes of action rather than individual carcinogens, because the same compound can affect carcinogenesis in more than one way. Basically, we categorize modes of action as: (1) co-initiation (facilitating the original mutagenic changes in stem and progenitor cells that start the cancer process) (e.g. induction of activating enzymes for other carcinogens); (2) promotion… CONTINUE READING

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