A preliminary investigation of promotion of brain tumours by hexachlorophane in Sprague-Dawley rats transplacentally exposed to N-ethylnitrosourea.

@article{Purves1992API,
  title={A preliminary investigation of promotion of brain tumours by hexachlorophane in Sprague-Dawley rats transplacentally exposed to N-ethylnitrosourea.},
  author={D C Purves and Anthony D. Dayan},
  journal={Neuropathology and applied neurobiology},
  year={1992},
  volume={18 3},
  pages={259-64}
}
Two-stage carcinogenesis (initiation and promotion) has been demonstrated in various mammalian tissues, but there is no conclusive evidence that it occurs in the nervous system. The present work has investigated the possibility that it might occur in the brain of the rat. Pregnant Sprague-Dawley rats were given an initiating dose (10 mg/kg intravenously (i… CONTINUE READING