A preliminary clinical experience with reduced glutathione as protector against cisplatin-toxicity.

@article{Oriana1987APC,
  title={A preliminary clinical experience with reduced glutathione as protector against cisplatin-toxicity.},
  author={S. S. Oriana and Silvia B{\"o}hm and Gian Battista Spatti and Franco Zunino and F. Di Re},
  journal={Tumori},
  year={1987},
  volume={73 4},
  pages={
          337-40
        }
}
A total of 16 consecutive patients (15 with ovarian cancer and 1 with unknown adenocarcinoma) were treated with a standard regimen including cisplatin and cyclophosphamide or with the same regimen in combination with reduced glutathione as potential protective agent against cisplatin nephrotoxicity, in a non-randomized study. Reduced glutathione (1500 mg/m2) was administered prior to each cisplatin administration (90 mg/m2) to seven patients for a maximum of five consecutive courses. A standard… CONTINUE READING
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