A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4.

@article{Gaohua2012APP,
  title={A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4.},
  author={Lu Gaohua and Khaled Abduljalil and Masoud Jamei and Trevor N. Johnson and Amin Rostami-Hodjegan},
  journal={British journal of clinical pharmacology},
  year={2012},
  volume={74 5},
  pages={873-85}
}
AIMS Pregnant women are usually not part of the traditional drug development programme. Pregnancy is associated with major biological and physiological changes that alter the pharmacokinetics (PK) of drugs. Prediction of the changes to drug exposure in this group of patients may help to prevent under- or overtreatment. We have used a pregnancy physiologically based pharmacokinetic (p-PBPK) model to assess the likely impact of pregnancy on three model compounds, namely caffeine, metoprolol and… CONTINUE READING