A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

  title={A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates},
  author={Annette B. Vogel and Isis Kanevsky and Ye Che and Kena A. Swanson and Alexander Muik and Mathias Vormehr and Lena M. Kranz and Kerstin C. Walzer and Stephanie Hein and Alptekin G{\"u}ler and Jakob Loschko and Mohan S. Maddur and Kristin R Tompkins and Journey Cole and Bonny Gaby Lui and Thomas Ziegenhals and Arianne Plaschke and David Eisel and Sarah C. Dany and Stephanie Fesser and Stephanie Erbar and Ferdia Bates and Diana Schneider and Bernadette Jesionek and Bianca S{\"a}nger and Anna Wallisch and Yvonne Feuchter and Hanna Junginger and Stefanie A. Krumm and Andr{\'e} P. Heinen and Petra Adams-Quack and Julia Schlereth and Christoph Kröner and Shannan Hall-Ursone and Kathleen M. Brasky and Matthew C. Griffor and Seungil Han and Joshua A. Lees and Ellene H Mashalidis and Parag V. Sahasrabudhe and Charles Y. Tan and Danka Pavliakova and Guy Singh and Camila R Fontes-Garfias and Michael Pride and Ingrid Scully and Tara Ciolino and Jennifer Obregon and Michal Gazi and Ricardo Carrion and Kendra J. Alfson and Warren Vincent Kalina and Deepak Kaushal and Pei-Yong Shi and Thorsten Klamp and Corinna Rosenbaum and Andreas N. Kuhn and {\"O}zlem T{\"u}reci and Philip R. Dormitzer and Kathrin U. Jansen and Uğur Şahin},
To contain the coronavirus disease 2019 (COVID-19) pandemic, a safe and effective vaccine against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is urgently needed in quantities sufficient to immunise large populations. In this study, we report the design, preclinical development, immunogenicity and anti-viral protective effect in rhesus macaques of the BNT162b2 vaccine candidate. BNT162b2 contains an LNP-formulated nucleoside-modified mRNA that encodes the spike… 

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