A preferred target DNA structure for retroviral integrase in vitro.

@article{Katz1998APT,
  title={A preferred target DNA structure for retroviral integrase in vitro.},
  author={Richard A. Katz and Kelly L. Gravuer and Anna Marie Ann Skalka},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 37},
  pages={
          24190-5
        }
}
The retroviral integrase protein catalyzes the insertion of linear viral DNA ends into the host cell DNA. Although integration in vivo is not site-specific, the detection of local and regional preferences within cellular DNA suggests that the integration reaction can be influenced by specific features of host DNA or chromatin. Here we describe highly preferred in vitro integration sites for avian sarcoma virus and human immunodeficiency virus-1 integrases within the stems of plasmid DNA… CONTINUE READING
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