A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality.

@article{Loo2005APC,
  title={A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality.},
  author={Vivian G. Loo and Louise Poirier and Mark A. Miller and Matthew Oughton and Michael D Libman and Sophie Michaud and Annette M. Bourgault and Tuyen Nguyen and Charles H. Frenette and Mirabelle Kelly and Anne Vibien and Paul Brassard and Susan Fenn and Ken Dewar and Thomas J. Hudson and Ruth Horn and Pierre René and Yury Monczak and Andr{\'e} Dascal},
  journal={The New England journal of medicine},
  year={2005},
  volume={353 23},
  pages={
          2442-9
        }
}
BACKGROUND In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile-associated diarrhea. METHODS In 2004 we conducted a prospective study at 12 Quebec hospitals to determine the incidence of nosocomial C. difficile-associated diarrhea and its complications and a case-control study to identify risk factors for the disease. Isolates of C. difficile were typed by pulsed-field gel electrophoresis and analyzed for binary toxin genes and… 

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