A predictive modeling approach for cell line-specific long-range regulatory interactions

  title={A predictive modeling approach for cell line-specific long-range regulatory interactions},
  author={Sushmita Roy and Alireza F. Siahpirani and Deborah Chasman and Sara A Knaack and Ferhat Ay and Ron M. Stewart and Michael D. Wilson and Rupa Sridharan},
  booktitle={Nucleic acids research},
Long range regulatory interactions among distal enhancers and target genes are important for tissue-specific gene expression. Genome-scale identification of these interactions in a cell line-specific manner, especially using the fewest possible datasets, is a significant challenge. We develop a novel computational approach, Regulatory Interaction Prediction for Promoters and Long-range Enhancers (RIPPLE), that integrates published Chromosome Conformation Capture (3C) data sets with a minimal… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 15 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
16 Citations
56 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 56 references

Optimization with Sparsity-Inducing Penalties

  • F. Bach, R. Jenatton, J. Mairal, G. Obozinski
  • Found. Trends Mach. Learn.,
  • 2012
Highly Influential
13 Excerpts

Similar Papers

Loading similar papers…