A predictive modeling approach for cell line-specific long-range regulatory interactions

@inproceedings{Roy2015APM,
  title={A predictive modeling approach for cell line-specific long-range regulatory interactions},
  author={Sushmita Roy and Alireza F. Siahpirani and Deborah Chasman and Sara A Knaack and Ferhat Ay and Ron M. Stewart and Michael D. Wilson and Rupa Sridharan},
  booktitle={Nucleic acids research},
  year={2015}
}
Long range regulatory interactions among distal enhancers and target genes are important for tissue-specific gene expression. Genome-scale identification of these interactions in a cell line-specific manner, especially using the fewest possible datasets, is a significant challenge. We develop a novel computational approach, Regulatory Interaction Prediction for Promoters and Long-range Enhancers (RIPPLE), that integrates published Chromosome Conformation Capture (3C) data sets with a minimal… CONTINUE READING
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