A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Abstract

The resistance of Caenorhabditis elegans to pharmacological perturbation limits its use as a screening tool for novel small bioactive molecules. One strategy to improve the hit rate of small-molecule screens is to preselect molecules that have an increased likelihood of reaching their target in the worm. To learn which structures evade the worm's defenses… (More)
DOI: 10.1038/nchembio.380

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