A predictive method for the evaluation of peptide binding in pocket 1 of HLA-DRB1 via global minimization of energy interactions.

@article{Androulakis1997APM,
  title={A predictive method for the evaluation of peptide binding in pocket 1 of HLA-DRB1 via global minimization of energy interactions.},
  author={Ioannis Androulakis and Nirmala N Nayak and Marianthi G. Ierapetritou and Dimitri S. Monos and Christodoulos A. Floudas},
  journal={Proteins},
  year={1997},
  volume={29 1},
  pages={
          87-102
        }
}
Human leukocyte antigens (HLA) or histocompatibility molecules are glycoproteins that play a pivotal role in the development of an effective immune response. An important function of the HLA molecules is the ability to bind and present antigen peptides to T lymphocytes. Presently there is no comprehensive way of predicting and energetically evaluating peptide binding on HLA molecules. To quantitatively determine the binding specificity of a class II HLA molecule interacting with peptides, a… CONTINUE READING

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