A predictive fitness model for influenza

@article{uksza2014APF,
  title={A predictive fitness model for influenza},
  author={Marta Łuksza and M. L{\"a}ssig},
  journal={Nature},
  year={2014},
  volume={507},
  pages={57-61}
}
  • Marta Łuksza, M. Lässig
  • Published 2014
  • Biology, Medicine
  • Nature
  • The seasonal human influenza A/H3N2 virus undergoes rapid evolution, which produces significant year-to-year sequence turnover in the population of circulating strains. Adaptive mutations respond to human immune challenge and occur primarily in antigenic epitopes, the antibody-binding domains of the viral surface protein haemagglutinin. Here we develop a fitness model for haemagglutinin that predicts the evolution of the viral population from one year to the next. Two factors are shown to… CONTINUE READING
    284 Citations

    Figures and Topics from this paper

    Evolution: Flu fitness model may inform vaccine selection
    Computational Prediction of Vaccine Strains for Human Influenza A (H3N2) Viruses
    • 29
    • PDF
    The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans
    • 44
    • Highly Influenced
    • PDF
    Selecting vaccine strains for H3N2 human influenza A virus
    • 12
    • Highly Influenced
    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution
    • Highly Influenced
    • PDF
    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution
    • 5
    • Highly Influenced
    • PDF
    Selection on non-antigenic gene segments of seasonal influenza A virus and its impact on adaptive evolution
    • Highly Influenced
    Predicting the Mutating Distribution at Antigenic Sites of the Influenza Virus
    • 6
    • PDF
    Selection on non-antigenic gene segments of seasonal influenza A virus and its impact on adaptive evolution
    • 10
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 57 REFERENCES
    Clonal Interference in the Evolution of Influenza
    • 132
    • PDF
    The genomic rate of molecular adaptation of the human influenza A virus.
    • 115
    • PDF
    Mapping the Antigenic and Genetic Evolution of Influenza Virus
    • 1,318
    • PDF
    Predicting the evolution of human influenza A.
    • 489
    • PDF
    The Global Circulation of Seasonal Influenza A (H3N2) Viruses
    • 629
    Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus
    • 236
    • PDF