A predictive and feedback control algorithm maintains a constant glucose concentration in fed-batch fermentations.

@article{Kleman1991APA,
  title={A predictive and feedback control algorithm maintains a constant glucose concentration in fed-batch fermentations.},
  author={G L Kleman and Jeffery J Chalmers and G W Luli and William R. Strohl},
  journal={Applied and environmental microbiology},
  year={1991},
  volume={57 4},
  pages={910-7}
}
A combined predictive and feedback control algorithm based on measurements of the concentration of glucose on-line has been developed to control fed-batch fermentations of Escherichia coli. The predictive control algorithm was based on the on-line calculation of glucose demand by the culture and plotting a linear regression to the next datum point to obtain a predicted glucose demand. This provided a predictive "coarse" control for the glucose-based nutrient feed. A direct feedback control… CONTINUE READING

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Showing 1-10 of 26 references

Effect and control of glucose feeding on bacitracin production by fed - batch culture of Bacillus licheniformis

  • T. Suzuki, T. Yasuda, T. Yamane, S. Shimizu
  • J . Ferment . Technol .
  • 1988

Effect of activity of primary proton pumps on growth of Escherichia coli in the presence of acetate

  • W. R. Strohl, P. L. Lorensen, S. M. Schlasner
  • Mikrobiologiya
  • 1988

On - line HPLC - measurement and control of substrate in a continuously operated biological tank reactor

  • H. Bennemann, H. Herbst, S. Dormeier
  • 1988

A gradient - feed process for E . coli fermentations

  • A. Fiechter
  • Biopharm . Manuf .
  • 1987

An automatic , on - line glucose analyzer for feedback control of fed - batch growth of Escherichia coli

  • G. W. Luli
  • Biotech - nol . Tech .
  • 1987

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