A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis.

@article{Chen2007APS,
  title={A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis.},
  author={Mark S. Chen and M Christina White},
  journal={Science},
  year={2007},
  volume={318 5851},
  pages={783-7}
}
Realizing the extraordinary potential of unactivated sp3 C-H bond oxidation in organic synthesis requires the discovery of catalysts that are both highly reactive and predictably selective. We report an iron (Fe)-based small molecule catalyst that uses hydrogen peroxide (H2O2) to oxidize a broad range of substrates. Predictable selectivity is achieved solely on the basis of the electronic and steric properties of the C-H bonds, without the need for directing groups. Additionally, carboxylate… CONTINUE READING
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