A preclinical study to investigate the development of nephrogenic systemic fibrosis: a possible role for gadolinium-based contrast media.

@article{Sieber2008APS,
  title={A preclinical study to investigate the development of nephrogenic systemic fibrosis: a possible role for gadolinium-based contrast media.},
  author={Martin Andrew Sieber and Hubertus Pietsch and Jakob E. Walter and Wolfram Haider and Thomas Frenzel and H. -J. Weinmann},
  journal={Investigative radiology},
  year={2008},
  volume={43 1},
  pages={65-75}
}
OBJECTIVES Several recent publications have suggested an association between the administration of gadolinium (Gd)-based contrast agents and the occurrence of Nephrogenic Systemic Fibrosis (NSF), an acquired disorder marked by skin thickening and fibrosis occurring in patients with severe renal dysfunction. The aim of this study was to establish a preclinical experimental setting to investigate the possible link between NSF and Gd-based contrast agents, and specifically the role of Gd and/or… CONTINUE READING

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