A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to d -amfetamine, methylphenidate and modafinil

@article{Heal2013APE,
  title={A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to 
 d
 -amfetamine, methylphenidate and modafinil},
  author={David J. Heal and Niki W. Buckley and Jane Gosden and Nigel Slater and Charles P. France and David Hackett},
  journal={Neuropharmacology},
  year={2013},
  volume={73},
  pages={348-358}
}

Figures and Tables from this paper

Differences in the neurochemical and behavioural profiles of lisdexamfetamine methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats
TLDR
The neurochemical and behavioural profiles of lisdexamfetamine, methylphenidate and modafinil were compared by dual-probe microdialysis in the prefrontal cortex (PFC) and striatum of conscious rats with simultaneous locomotor activity measurement, showing larger and more sustained effects on catecholaminergic neurotransmission.
Lisdexamfetamine: chemistry, pharmacodynamics, pharmacokinetics, and clinical efficacy, safety, and tolerability in the treatment of binge eating disorder
TLDR
LDX is the first medication with United States Food and Drug Administration approval for the treatment of BED and is an inactive prodrug of d-amphetamine that extends the half-life ofd-amphetamine to allow for once daily dosing.
Distinct effects of (R)‐modafinil and its (R)‐ and (S)‐fluoro‐analogs on mesolimbic extracellular dopamine assessed by voltammetry and microdialysis in rats
Psychostimulant use disorders remain an unabated public health concern worldwide, but no FDA approved medications are currently available for treatment. Modafinil (MOD), like cocaine, is a dopamine
Potential for Dependence on Lisdexamfetamine - In vivo and In vitro Aspects
TLDR
Performing high performance liquid chromatography studies on synaptosomes can aid in predicting dependence liability when studying new psychoactive substances in the future.
Oral modafinil facilitates intracranial self-stimulation in rats: comparison with methylphenidate
TLDR
The effects of orally administered modafinil in rats using an assay of intracranial self-stimulation (ICSS) that has been used to examine the effects of other DAT inhibitors are evaluated, showing the sensitivity of ICSS to orally administered drug.
Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure
TLDR
Lisdexamfetamine has a slower onset and longer duration of action than amphetamine but retains amphetamine’s efficacy to reduce the choice of cocaine in rhesus monkeys, and these results support further consideration of lisdexemfetamine as an agonist-based medication candidate for cocaine addiction.
Effects of modafinil and R-modafinil on brain stimulation reward thresholds: implications for their use in the treatment of psychostimulant dependence.
TLDR
Modaf inil and R-modafinil have limited effects on brain reward function in otherwise drug-naïve subjects.
...
1
2
3
4
...

References

SHOWING 1-10 OF 83 REFERENCES
An evaluation of the abuse potential of modafinil using methylphenidate as a reference
  • D. Jasinski
  • Psychology, Medicine
    Journal of psychopharmacology
  • 2000
TLDR
The profile of physiological effects for modafinil differed from methylphenidate in that it showed greater inhibition of observed and reported sleep, less facilitation of orthostatic tachycardia and less reduction of caloric intake, consistent with preclinical pharmacological data suggesting that modaf inil is not an amphetamine-like agent.
Human pharmacology of intravenous lisdexamfetamine dimesylate: abuse liability in adult stimulant abusers
TLDR
LDX administered intravenously did not produce significant subjective abuse-related liking scores at assessed doses, and was well tolerated in this population of adult substance abusers.
Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse
TLDR
At an equivalent amount of amphetamine base taken orally, LDX 100 mg had attenuated responses on measures of abuse liability compared with immediate-release d-amphetamine 40 mg, and diethylpropion hydrochloride, a Schedule IV amphetamine-like stimulant, on abuse-related liking scores.
Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil
TLDR
The data show that modafinil interacts with DAT sites in rat brain, a property shared with agonist medications under investigation for treating cocaine dependence, and suggest that modAFinil should be tested as an adjunct for treating METH addiction.
Evaluation of the cocaine-like discriminative stimulus effects and reinforcing effects of modafinil
TLDR
Results show that modafinil has some cocaine-like discriminative stimulus effects and, like other abused stimulants, can serve as a reinforcer at high doses.
Intranasal versus Oral Administration of Lisdexamfetamine Dimesylate
TLDR
IN administration of lisdexamfetamine dimesylate resulted in d-amphetamine plasma concentrations and systemic exposure to d- methamphetamine comparable to those seen with PO administration and both PO and IN demonstrated a tolerability profile similar to that of other long-acting stimulants.
Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro
TLDR
The present data provide compelling evidence that modafinil occupies the DAT and NET in living brain of rhesus monkeys and raise the possibility that modAFinil affects wakefulness by interacting with catecholamine transporters in brain.
Methylphenidate and its Isomers
TLDR
It is concluded that d-threo-methylphenidate, which is the more potent and abundant of the two isomers, is the major contributor of both efficacy and adverse effects, irrespective of the formulation or route of administration of the racemate.
A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine
TLDR
The data indicate that dopamine is unlikely to be an important pharmacological target for reuptake inhibition by sibutramine, and the rank order of potency for enhancing central dopaminergic function is methamphetamine > bupropion >> sibUTramine.
...
1
2
3
4
5
...