A preclinical animal model to assess the effect of pre-existing immunity on AAV-mediated gene transfer.

@article{Li2009APA,
  title={A preclinical animal model to assess the effect of pre-existing immunity on AAV-mediated gene transfer.},
  author={Hua Liang Li and Shih-wen Lin and Wynetta Giles-Davis and Yan Li and Dongming Zhou and Z. Q. Xiang and K. A. High and Hildegund C. J. Ertl},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2009},
  volume={17 7},
  pages={
          1215-24
        }
}
Hepatic adeno-associated virus (AAV)-serotype 2-mediated gene transfer results in sustained transgene expression in experimental animals but not in human subjects. We hypothesized that loss of transgene expression in humans might be caused by immune memory mechanisms that become reactivated upon AAV vector transfer. Here, we tested the effect of immunological memory to AAV capsid on AAV-mediated gene transfer in a mouse model. Upon hepatic transfer of an AAV2 vector expressing human factor IX… CONTINUE READING
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