A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis.

@article{Sangster2006APA,
  title={A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis.},
  author={Timothy Sangster and Hilary Major and Robert Plumb and Amy J Wilson and Ian D Wilson},
  journal={The Analyst},
  year={2006},
  volume={131 10},
  pages={1075-8}
}
Metabonomic/metabolomic studies can involve the analysis of large numbers of samples for the detection of biomarkers and confidence in the analytical data, generated by methods such as GC and HPLC-MS, requires active measures on the part of the analyst. However, quality control for complex multi-component samples such as biofluids, where many of the components of interest in the sample are unknown prior to analysis, poses significant problems. Here the repeat analysis of a pooled sample… CONTINUE READING

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