A practical view of 'druggability'.

  title={A practical view of 'druggability'.},
  author={Thomas H Keller and Arkadius Pichota and Zheng Yin},
  journal={Current opinion in chemical biology},
  volume={10 4},
The introduction of Lipinski's 'Rule of Five' has initiated a profound shift in the thinking paradigm of medicinal chemists. Understanding the difference between biologically active small molecules and drugs became a priority in the drug discovery process, and the importance of addressing pharmacokinetic properties early during lead optimization is a clear result. These concepts of 'drug-likeness' and 'druggability' have been extended to proteins and genes for target identification and… CONTINUE READING

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