A practical view of 'druggability'.

@article{Keller2006APV,
  title={A practical view of 'druggability'.},
  author={Thomas H Keller and Arkadius Pichota and Zheng Yin},
  journal={Current opinion in chemical biology},
  year={2006},
  volume={10 4},
  pages={357-61}
}
The introduction of Lipinski's 'Rule of Five' has initiated a profound shift in the thinking paradigm of medicinal chemists. Understanding the difference between biologically active small molecules and drugs became a priority in the drug discovery process, and the importance of addressing pharmacokinetic properties early during lead optimization is a clear result. These concepts of 'drug-likeness' and 'druggability' have been extended to proteins and genes for target identification and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
65 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…