• Chemistry
  • Published 2000

A practical approach to stereodefined cyclopropyl-substituted heteroarenes using a Suzuki-type reaction

@inproceedings{2000APA,
  title={A practical approach to stereodefined cyclopropyl-substituted heteroarenes using a Suzuki-type reaction},
  author={姚敏良 and 邓敏智},
  year={2000}
}
In the presence of Pd(PPh^3)^4, NaBr and KF.2H^2O the cross-coupling reaction of heteroaryl triflates with trans-cyclopropylboronic acids proceeds readily to give pure trans-cyclopropyl heteroarenes in moderate to good yields. The X-ray crystallography of compound 3g and ~1H-NMR spectra of all products show that the configuration of the cyclopropyl group was retained during the reaction. Under the same reaction conditions. Highly optically active cyclopropyl-substituted heteroarenes(up to 94… CONTINUE READING