A practical approach to minimize the interaction of dietary vitamin K with warfarin

@article{Chang2014APA,
  title={A practical approach to minimize the interaction of dietary vitamin K with warfarin},
  author={C.‐H. Chang and Y.‐W. Wang and P-Y Yeh Liu and Yea-Huei Kao Yang},
  journal={Journal of Clinical Pharmacy and Therapeutics},
  year={2014},
  volume={39}
}
WHAT IS KNOWN AND OBJECTIVE The many interactions between warfarin and other drugs and foods generate great challenges for clinicians and patients in maintaining stable anitcoagulation. [...] Key MethodRESULTS AND DISCUSSION The vitamin K score was equivalent to 5 points for spinach and garland chrysanthemum per bowel, followed by (baby) bok choy, amaranth, arden lettuce (4 points); leaf mustard, edible rape, sweet potato leaf, bai cai and Chinese leek (3 points); and okra and Chinese celery (0·5 points). This…Expand
Warfarin drug interaction with vitamin K and other foodstuffs
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The aim of this study was to gather information on the drug interaction of warfarin with vitamin K and with dietary supplements and other foods. Expand
Association Between Usual Vitamin K Intake and Anticoagulation in Patients Under Warfarin Therapy
TLDR
No statistically significant correlation was found between usual vitamin K intake and percent TTR and anticoagulant effects and development of assessment tools to measure inter-individual variability of vitamin K Intake might be helpful. Expand
Relationship between Mediterranean diet and time in therapeutic range in atrial fibrillation patients taking vitamin K antagonists.
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  • 2015
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In this cohort of AF patients, Med-Diet is not associated with changes in TTR, and thus can be recommended for AF patients who are taking VKAs. Expand
Use of Non-Vitamin K Antagonist Oral Anticoagulants in Special Patient Populations with Nonvalvular Atrial Fibrillation: A Review of the Literature and Application to Clinical Practice
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The objective of this review is to provide the clinician with an update on the use of NOACs for NVAF, focusing on older adults and patients with renal impairment in light of recently published atrial fibrillation guidelines. Expand
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The most common interactions the NP may encounter in primary care practice are described and a thorough and detailed health history and dietary recall are essential for identifying potential problems when prescribing or evaluating medication efficacy. Expand
Methods for assessment of Vitamin K
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  • 2019
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This chapter provides an overview of the important principles and practices relating to vitamin K measurement in diagnostic and research settings that will be helpful for laboratories in the setting up of analytical methods and also in the interpretation of the results. Expand
Drug interactions and adverse events in a cohort of Warfarin users attending Public Health Clinics
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This was an open cohort, prospective study conducted in an 18-month period with warfarin users attending public health clinics of the city of Ijuí, Brazil, and vitamin K consumption was quantified using a validated method. Expand
Delivering personalized dietary advice for health management and disease prevention
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This study built and demonstrated a tool that provides personalized dietary advice that accounts for a patient's combination of disease and drugs in real-time on their mobile device and showed that digital health tools can provide highly contextual and adaptive responses from a single knowledge graph. Expand
RelationshipbetweenMediterraneandietandtime in therapeutic range in atrial fibrillation patients taking vitamin K antagonists
Methods and results A prospective observational study including 553 non-valvular AF patients. Time in therapeutic range was calculated for all patients treated with VKAs, and adherence to Med-DietExpand
Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients
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Five variables, that is, age, gender, smoking, alcoholism, and diet, were found to be significantly associated with warfarin response in univariate analysis and will help in prescribing more accurate warfarIn maintenance dosing in Indian patients and will also help in minimizing warfar in-induced adverse drug reactions and a better quality of life in these patients. Expand
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The scope and potential clinical impact of the most commonly reported food, dietary supplement and herbal interactions with warfarin therapy are discussed and practical steps for patients and providers to minimise these interactions are highlighted. Expand
Improved Oral Anticoagulation After a Dietary Vitamin K–Guided Strategy: A Randomized Controlled Trial
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A vitamin K–guided management strategy to adjust long-term oral anticoagulation is feasible and safe and may result in an increased chance of reaching target levels of INR. Expand
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Clinicians need to be vigilant when initiating any of these agents or when any changes in the patient’s medication profile occur and perform a close screening for potential drug and dietary interactions. Expand
Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation.
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Daily supplementation with oral vitamin K in unstable patients could lead to a more stable anticoagulation response to warfarin. Expand
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A consistent intake of vitamin K could reduce intrapatient variability in anticoagulation response and thus improve the safety of warfarin therapy. Expand
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It is concluded that vitamin K(1)-containing multivitamin supplements reduce INR in patients with low vitamin K-depleted status, and these patients are sensitive to even small changes in vitamin K (1) intake. Expand
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