A practical approach in bioreactor scale-up and process transfer using a combination of constant P/V and vvm as the criterion.

@article{Xu2017APA,
  title={A practical approach in bioreactor scale-up and process transfer using a combination of constant P/V and vvm as the criterion.},
  author={Sen Xu and Linda Hoshan and Rubin Jiang and Balrina Gupta and Eric Brodean and Kristin O'Neill and T. Craig Seamans and John Bowers and Hao Chen},
  journal={Biotechnology progress},
  year={2017},
  volume={33 4},
  pages={
          1146-1159
        }
}
Bioreactor scale-up is a critical step in the production of therapeutic proteins such as monoclonal antibodies (MAbs). With the scale-up criterion such as similar power input per volume or O2 volumetric mass transfer coefficient ( kLa), adequate oxygen supply and cell growth can be largely achieved. However, CO2 stripping in the growth phase is often inadequate. This could cascade down to increased base addition and osmolality, as well as residual lactate increase and compromised production and… CONTINUE READING

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