A practical approach for linearity assessment of calibration curves under the International Union of Pure and Applied Chemistry (IUPAC) guidelines for an in-house validation of method of analysis.

@article{Sanagi2010APA,
  title={A practical approach for linearity assessment of calibration curves under the International Union of Pure and Applied Chemistry (IUPAC) guidelines for an in-house validation of method of analysis.},
  author={Mohd Marsin Sanagi and Zalilah Nasir and Susie Lu Ling and Dadan Hermawan and Wan Aini Wan Ibrahim and Ahmedy Abu Naim},
  journal={Journal of AOAC International},
  year={2010},
  volume={93 4},
  pages={1322-30}
}
Linearity assessment as required in method validation has always been subject to different interpretations and definitions by various guidelines and protocols. However, there are very limited applicable implementation procedures that can be followed by a laboratory chemist in assessing linearity. Thus, this work proposes a simple method for linearity assessment in method validation by a regression analysis that covers experimental design, estimation of the parameters, outlier treatment, and… CONTINUE READING

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