A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care.
@article{Mourtzakis2008APA, title={A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care.}, author={Marina Mourtzakis and Carla M. M. Prado and Jessica R.L. Lieffers and Tony Reiman and Linda Mccargar and Vickie E. Baracos}, journal={Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme}, year={2008}, volume={33 5}, pages={ 997-1006 } }
Human body composition is important in numerous cancer research domains. Our objective was to evaluate clinically accessible methods to achieve practical and precise measures of body composition in cancer patients. Dual-energy X-ray absorptiometry (DXA)-based analysis of fat and fat-free mass was performed in 50 cancer patients and compared with bioelectrical impedance analysis (BIA) and with regional computed tomography (CT) images available in the patients' medical records. BIA overestimated…
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References
SHOWING 1-10 OF 47 REFERENCES
Bedside methods versus dual energy X‐ray absorptiometry for body composition measurement in COPD
- MedicineEuropean Respiratory Journal
- 2002
Two bedside methods for the measurement of body composition using dual energy X‐ray absorptiometry (DEXA) as a reference method are compared and there are significant intermethod differences.
Visceral fat accumulation as a risk factor for prostate cancer.
- MedicineObesity research
- 2004
A role for visceral obesity, quantified by CT, as a risk factor for prostate cancer is suggested, and the action of the adipocytokines secreted by visceral fat cells, steroid hormone disturbances, and increased levels of insulin or other hormones noted in visceral obesity may explain this association.
The emerging role of computerized tomography in assessing cancer cachexia
- Medicine, BiologyCurrent opinion in supportive and palliative care
- 2009
CT images routinely acquired from health records of cancer patients can be used to quantify specific lean and adipose tissues, to interpret body composition in population-based studies, and to evaluate individual patients in a clinical and therapeutic decision-making setting.
Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image.
- MedicineJournal of applied physiology
- 2004
Investigation of the relationships between abdominal SM and AT areas from single images and total body component volumes in a large and diverse sample of healthy adult subjects found that measurement of a single abdominal image can provide estimates of total bodySM and AT for group studies of healthy adults.
Tissue components of weight loss in cancer patients. A new method of study and preliminary observations
- MedicineCancer
- 1985
This initial study suggests that the principal endogenous energy and nitrogen sources during evolution of weight loss in cancer are primarily adipose tissue triglycerides and skeletal muscle proteins.
New bioelectrical impedance formula for patients with respiratory insufficiency: comparison to dual-energy X-ray absorptiometry.
- MedicineThe European respiratory journal
- 1998
A prediction equation, validated against dual-energy X-ray absorptiometry and based on subjects with similar clinical characteristics, is more applicable to the patients with respiratory insufficiency than a formula developed for healthy subjects.
Bioelectrical impedance analysis-part II: utilization in clinical practice.
- MedicineClinical nutrition
- 2004
Visceral adipose tissue: relations between single-slice areas and total volume.
- MedicineThe American journal of clinical nutrition
- 2004
Investigation of the relations between cross-sectional VAT areas at different anatomic locations and VAT volume in a large, diverse sample of healthy subjects found measurement of slice areas at A(+10) in men and A (+5) in women provides greater power for the detection of VAT volume differences than does measurement at L4-L5.
Comparison of body weight and composition measured by two different dual energy X-ray absorptiometry devices and three acquisition modes in obese women.
- MedicineClinical nutrition
- 2006
Evaluation of foot-to-foot bioelectrical impedance analysis for the prediction of total body water in oncology outpatients receiving radiotherapy
- MedicineEuropean Journal of Clinical Nutrition
- 2004
There is good agreement between foot-to-foot bioelectrical impedance with a gold standard technique at the group level, however, the significant correlation between the difference of predicted and measured TBW, and the wide limits of agreement between the two methods, indicates that the use of foot- to-foot impedance in assessing TBW may lead to unacceptable error in individuals.