A practical Lewis base catalyzed electrophilic chlorination of arenes and heterocycles.

Abstract

A mild phosphine sulfide catalyzed electrophilic halogenation of arenes and heterocycles that utilizes inexpensive and readily available N-halosuccinimides is disclosed. This methodology is shown to efficiently chlorinate diverse aromatics, including simple arenes such as anthracene, and heterocycles such as indoles, pyrrolopyrimidines, and imidazoles… (More)
DOI: 10.1021/acs.orglett.5b00186

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