A poxvirus protein that binds to and inactivates IL-18, and inhibits NK cell response.

@article{Born2000APP,
  title={A poxvirus protein that binds to and inactivates IL-18, and inhibits NK cell response.},
  author={Teresa L. Born and Lynda A Morrison and David J. Esteban and T Vandenbos and Lydia G. Thebeau and Nana Chen and Melanie K. Spriggs and J. E. Sims and R. Mark L. Buller},
  journal={Journal of immunology},
  year={2000},
  volume={164 6},
  pages={3246-54}
}
IL-18 induces IFN-gamma and NK cell cytotoxicity, making it a logical target for viral antagonism of host defense. We demonstrate that the ectromelia poxvirus p13 protein, bearing homology to the mammalian IL-18 binding protein, binds IL-18, and inhibits its activity in vitro. Binding of IL-18 to the viral p13 protein was compared with binding to the cellular IL-18R. The dissociation constant of p13 for murine IL-18 is 5 nM, compared with 0.2 nM for the cellular receptor heterodimer. Mice… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Viral interference with innate immunity by preventing NF-κB activity.

Cellular microbiology • 2012
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…