A powerful test for multiple rare variants association studies that incorporates sequencing qualities

@inproceedings{Daye2012APT,
  title={A powerful test for multiple rare variants association studies that incorporates sequencing qualities},
  author={Z. John Daye and Hongzhe Li and Zhi Wei},
  booktitle={Nucleic acids research},
  year={2012}
}
Next-generation sequencing data will soon become routinely available for association studies between complex traits and rare variants. Sequencing data, however, are characterized by the presence of sequencing errors at each individual genotype. This makes it especially challenging to perform association studies of rare variants, which, due to their low minor allele frequencies, can be easily perturbed by genotype errors. In this article, we develop the quality-weighted multivariate score… CONTINUE READING
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A catalog of published genome-wide association studies

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