A potentially hazardous interaction between erythromycin and midazolam.

@article{Olkkola1993APH,
  title={A potentially hazardous interaction between erythromycin and midazolam.},
  author={Klaus T. Olkkola and Kari Aranko and Harri O Luurila and Alison Hiller and Laila Saarnivaara and Johan. Himberg and Pertti J Neuvonen},
  journal={Clinical pharmacology and therapeutics},
  year={1993},
  volume={53 3},
  pages={
          298-305
        }
}
Interaction between erythromycin and midazolam was investigated in two double-blind, randomized, crossover studies. In the first study, 12 healthy volunteers were given 500 mg erythromycin three times a day or placebo for 1 week. On the sixth day, the subjects ingested 15 mg midazolam. In the second study, midazolam (0.05 mg/kg) was given intravenously to six of the same subjects, after similar pretreatments. Plasma samples were collected, and psychomotor performance was measured. Erythromycin… CONTINUE READING
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