A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α–positive tumors

Abstract

Deregulated accumulation of hypoxia-inducible factor-1α (HIF-1α) is a hallmark of many solid tumors. Directly targeting HIF-1α for therapeutics is challenging. Our finding that HIF-1α regulates secretion of heat shock protein-90α (Hsp90α) for cell migration raises the exciting possibility that targeting the secreted Hsp90α from HIF-1α-positive tumors has a… (More)
DOI: 10.1091/mbc.E11-06-0575

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@inproceedings{Sahu2012APC, title={A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α–positive tumors}, author={Divya Sahu and Zhengwei Zhao and Fred Tsen and Chieh-Fang Cheng and Ryan Park and Alan Jialun Situ and Jinyao Dai and Ariana Eginli and Sharmineh Shams and Mei Chen and Tobias S Ulmer and Peter E Conti and David T. Woodley and Wei Li}, booktitle={Molecular biology of the cell}, year={2012} }