A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity

@article{Straub1995APV,
  title={A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity},
  author={Richard E Straub and Charles J. Maclean and Francis Anthony O'Neill and John Pius Burke and Bernadette Murphy and Fiona Duke and Rosemarie Shinkwin and Bradley Todd Webb and Jie Zhang and Dermot P. J. Walsh and Kenneth S. Kendler},
  journal={Nature Genetics},
  year={1995},
  volume={11},
  pages={287-293}
}
In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for schizophrenia in region 6p24–22. The greatest lod score, assuming locus heterogeneity, is 3.51 (P = 0.0002) with D6S296. Another test, the C test, also supported linkage, the strongest results being obtained with D6S296 (P = 0.00001), D6S274 (P = 0.004) and D6S285 (P = 0.006). Non–parametric analysis yielded suggestive, but substantially weaker, findings. This locus appears to influence the… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 153 CITATIONS, ESTIMATED 39% COVERAGE

Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.

  • American journal of human genetics
  • 2003
VIEW 1 EXCERPT
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1995
2018

CITATION STATISTICS

  • 7 Highly Influenced Citations