A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.

@article{olak2014APT,
  title={A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.},
  author={Y. Çolak and A. Yeşil and H. Mutlu and O. Caklili and Celal Ulasoglu and E. Şenateş and M. Takır and O. Kostek and Y. Yılmaz and Feruze Yilmaz Enc and Guralp Tasan and I. Tuncer},
  journal={Journal of gastrointestinal and liver diseases : JGLD},
  year={2014},
  volume={23 3},
  pages={
          311-9
        }
}
Sirtuins (SIRTs) are members of the silent information regulator-2 family and act as nicotinamide adenine dinucleotide (NAD+)-dependent histone/protein deacetylases. The de-acetylation of proteins and histones results in an up- or down-regulation of gene transcription and protein function. In recent years, the regulatory action of the deacetylation activity of SIRT1 has been shown to have a positive impact on the pathophysiological mechanisms of nonalcoholic fatty liver disease (NAFLD). Among… Expand
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