A potential smoothing algorithm accurately predicts transmembrane helix packing

@article{Pappu1999APS,
  title={A potential smoothing algorithm accurately predicts transmembrane helix packing},
  author={Rohit V. Pappu and Garland R. Marshall and Jay W. Ponder},
  journal={Nature Structural Biology},
  year={1999},
  volume={6},
  pages={199-199}
}
Potential smoothing, a deterministic analog of stochastic simulated annealing, is a powerful paradigm for the solution of conformational search problems that require extensive sampling, and should be a useful tool in computational approaches to structure prediction and refinement. A novel potential smoothing and search (PSS) algorithm has been developed and applied to predict the packing of transmembrane helices. The highlight of this method is the efficient manner in which it circumvents the… CONTINUE READING

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