A potential role of the curry spice curcumin in Alzheimer's disease.


There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimer's disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small short-term studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.

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@article{Ringman2005APR, title={A potential role of the curry spice curcumin in Alzheimer's disease.}, author={John M. Ringman and Sally Ann Frautschy and Gregory M. Cole and Donna L. Masterman and Jeffrey L. Cummings}, journal={Current Alzheimer research}, year={2005}, volume={2 2}, pages={131-6} }