A potential role for targeted therapy in a subset of metastasizing adnexal carcinomas

@article{DiasSantagata2011APR,
  title={A potential role for targeted therapy in a subset of metastasizing adnexal carcinomas},
  author={Dora C Dias-Santagata and Quynh T Lam and Kristin E Bergethon and Gabrielle M. Baker and Anthony John Iafrate and Dinesh Rakheja and Mai M P Hoang},
  journal={Modern Pathology},
  year={2011},
  volume={24},
  pages={974-982}
}
Metastasizing adnexal carcinomas are rare; thus, currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional therapeutic approaches. We performed immunohistochemistry (epidermal growth factor receptor (EGFR), HER2, and CD117), EGFR and ERBB2 fluorescence in situ hybridization (FISH), and multiplexed SNaPshot® genotyping (testing for recurrent mutations in 15 cancer genes including BRAF, EGFR, KRAS… CONTINUE READING