A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder.

@article{Khairova2009APR,
  title={A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder.},
  author={Rushaniya A Khairova and Rodrigo Machado-Vieira and Jing Du and Husseini K. Manji},
  journal={The international journal of neuropsychopharmacology},
  year={2009},
  volume={12 4},
  pages={561-78}
}
A growing body of data suggests that hyperactivation of the immune system has been implicated in the pathophysiology of major depressive disorder (MDD). Several pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) have been found to be significantly increased in patients with MDD. This review focuses on these two cytokines based on multiple lines of evidence from genetic, animal behaviour, and clinical studies showing that altered levels of serum… CONTINUE READING
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