A potential role for islet-1 in post-natal angiogenesis and vasculogenesis.

  title={A potential role for islet-1 in post-natal angiogenesis and vasculogenesis.},
  author={Aya Barzelay and Jeremy Ben-Shoshan and Michal Entin-Meer and Sofia Maysel-Auslender and Arnon Afek and Iris Barshack and Gad Keren and Jacob George},
  journal={Thrombosis and haemostasis},
  volume={103 1},
The LIM-homeobox transcription factor islet-1 (Isl1) marks a cell population which gives rise to myocardial, pacemaker, endothelial and smooth muscle cells, which are derived from the secondary heart field during heart embryogenesis. Isl1+ precursors have the potential of self-renewal and differentiation into endothelial, cardiomyocyte and smooth muscle lineages. The primary objective of this study was to determine whether retroviral gene delivery of Isl1 to endothelial cells and mesenchymal… CONTINUE READING


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lead to cardiac , smooth muscle , and endothelial cell diversification

  • P Carmeliet
  • 2006

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